| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-06-01 |
| タイトル |
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タイトル |
Inhibition of FLT3 Expression by Green Tea Catechins in FLT3 Mutated-AML Cells |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
LY, Bui Thi Kim
CHI, Hoang Thanh
YAMAGUCHI, Makoto
KANO, Yasuhiko
HARA, Yukihiko
NAKANO, Kazumi
SATO, Yuko
WATANABE, Toshiki
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| 著者別名 |
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識別子Scheme |
WEKO |
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識別子 |
249 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by a block in differentiation and uncontrolled proliferation. FLT3 is a commonly mutated gene found in AML patients. In clinical trials, the presence of a FLT3-ITD mutation significantly correlates with an increased risk of relapse and dismal verall survival. Therefore, activated FLT3 is a promising molecular target for AML therapies. In this study, we have shown that green tea polyphenols including (2)- epigallocatechin-3-gallate (EGCG), (2)-epigallocatechin (EGC), and (2)-epicatechin-3-gallate (ECG) suppress the proliferation of AML cells. Interestingly, EGCG, EGC and ECG showed the inhibition of FLT3 expression in cell lines harboring FLT3 mutations. In the THP-1 cells harboring FLT3 wild-type, EGCG showed the suppression of cell proliferation but did not suppress the expression of FLT3 even at the concentration that suppress 100% cell proliferation. Moreover, EGCG-, EGC-and ECG-treated cells showed the suppression of MAPK, AKT and STAT5 phosphorylation. Altogether, we suggest that green tea polyphenols could serve as reagents for treatment or prevention of leukemia harboring FLT3 mutations. |
|
言語 |
en |
| 書誌情報 |
en : PLoS ONE
巻 8,
号 6,
p. e66378-e66378,
発行日 2013
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| 出版者 |
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出版者 |
PLoS ONE |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
19326203 |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
本文 (1.4 MB)
